![]() ![]() ĭimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs. Dimercaprol competes with the thiol groups for binding the metal ion, which is then excreted in the urine. Mechanism of action Īrsenic and some other heavy metals act by chelating with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme's activity. ĭimercaprol also shows effectiveness against snakebite by potently antagonizing the activity of Zn 2+-dependent snake venom metalloproteinases in vitro. Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson's disease. Wilson's disease is a genetic disorder in which copper builds up inside the liver and other tissues. Nonetheless, because it can have serious adverse effects, researchers have also pursued development of less toxic analogues, such as succimer. It is also used as an antidote to the chemical weapon Lewisite. Medical uses ĭimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, and it is an essential drug. It is on the World Health Organization's List of Essential Medicines. It has a very pungent odor.ĭimercaprol was first made during World War II. Dimercaprol is a chelator and works by binding with heavy metals. It is unclear if use in pregnancy is safe for the baby. It is not recommended for people with peanut allergies as it is typically formulated as a suspension in peanut oil. Ĭommon side effects include high blood pressure, pain at the site of the injection, vomiting, and fever. ![]() It may also be used for antimony, thallium, or bismuth poisoning, although the evidence for those uses is not very strong. Dimercaprol, also called British anti-Lewisite ( BAL), is a medication used to treat acute poisoning by arsenic, mercury, gold, and lead. ![]()
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